Notes and sources
Where every fact in this guide comes from
The other pages keep their sources out of the way so they stay easy to read. They all gather here. You do not need to read this page to look after your pet well, but it is here if you, or your vet, want to check a point.
How much weight each kind of source can carry
| Kind of source | What it can tell you | What it cannot |
|---|---|---|
| Federal rules and FDA pages | How a medicine may reach an animal, and what FDA has said. | Whether a given product helps your particular pet. |
| Approved drug labels | The species, use and warnings that were reviewed for that one product. | Anything about a different product that shares a word with it. |
| Studies in real pets | What happened to animals living at home with their owners. | A firm answer, when only a few animals took part. |
| Studies in lab animals | Early clues about how a substance behaves in a body. | What a product bought online will do in a pet. |
| Company announcements | That a company says a study has begun. | Results, which only a published study can show. |
Dates matter here
The checks behind this guide were made on September 30, 2026. That includes FDA's list of approved animal drug ingredients, its animal drug database, and searches of the medical literature.
A search that finds nothing is not proof that nothing exists. Where this guide says a study "was not found", that is exactly what it means.
Questions about pets that nobody can answer yet
- Has FDA ever acted against a peptide sold for pets? No such action was found, though not every FDA letter could be checked.
- What is really inside peptide products sold for dogs or cats? No published lab testing of them was found.
- How does a pet dog's or cat's body handle these online peptides? Only the lab beagle work on BPC-157 speaks to it.
- Could a vet have a pharmacy make up BPC-157 for one pet? No FDA statement on it was found, so that is a question for your vet.
- Can a video visit start a proper vet relationship in your state? It depends on the state, and your vet will know.
- What about chews and treats with collagen peptides? They follow different rules that are not covered here.
Federal rules and FDA pages
- 21 CFR Part 530, the federal rule on off-label drug use in animals: CFR is the Code of Federal Regulations, where federal rules are written down. This part covers vets using approved drugs in ways the label does not list, and the vet relationship.
- 21 CFR 201.128: how intended use is judged from a seller's claims.
- 21 CFR 511.1: the exemption for lab research animals and test tubes.
- FDA, Unapproved Animal Drugs: what makes a product an animal drug, and the three legal ways to sell one.
- FDA, concerns about unapproved animal drugs: why unchecked products worry the agency.
- FDA, checking whether an animal drug is legally marketed: label lines, NDC numbers and the caution statement.
- Animal Drugs @ FDA: the free database of approved animal drugs, searched September 30, 2026.
- FDA Green Book, active ingredients: the Green Book is FDA's monthly list of approved animal drugs; this is its ingredient list, report dated September 30, 2026.
- FDA, questions about animal drugs: including the warning about acetaminophen and cats.
- FDA, animal drug compounding: what compounding is and why it is not approval.
- FDA guidance on compounding animal drugs from bulk substances: the 2022 guidance and its label advice.
- FDA questions and answers on that guidance: including why price is not a medical reason to compound.
- FDA, vet relationships and telemedicine: why photos or video alone cannot start the federal relationship.
- FDA, bulk substances in human compounding: its concerns about BPC-157, TB-500 and GHK-Cu in people, page current as of April 22, 2026.
- FDA, how to report a side effect or product problem.
- FDA, xylitol and dogs.
- FDA, pain relievers for pets: NSAID cautions for cats and blood tests for dogs.
- FDA, approved versus compounded pet medicines.
- FDA, medication errors happen to pets too.
- FDA, questions for your vet.
- FDA, the journey of an animal drug through approval: species-by-species safety testing.
State rules on the vet relationship
- California Business and Professions Code section 4826.6: video exams and their limits.
- Veterinary Medical Board of California, questions on the video-visit law: the written prescription offer.
- Texas Occupations Code chapter 801: section 801.351 on starting the vet relationship.
Studies in dogs and cats
- Xu and colleagues, 2020: early safety testing of BPC-157, including lab dogs.
- He and colleagues, 2022: how rats and lab beagles handled BPC-157.
- Swaim and colleagues, 1996: paw pad wounds in lab dogs.
- Davison and colleagues, 2008: insulin antibodies in diabetic dogs.
- Dik and colleagues, 2025: liraglutide in overweight older dogs.
- Dobenecker and colleagues, 2024: an oral collagen supplement in dogs with arthritis.
- Court, 2013: how cats clear drugs differently.
- Riederer and colleagues, 2016: exenatide in newly diabetic cats.
- Hoelmkjaer and colleagues, 2016: exenatide in overweight pet cats.
- Gilor and colleagues, 2025: exenatide in cats already in remission.
- Schneider and colleagues, 2020: how long exenatide lasts in cats.
- PubMed: the literature searches run on September 30, 2026, which found no treatment study of BPC-157 or TB-500 in pet dogs or cats.
Product testing and warnings about people
- Ashraf and colleagues, 2024: semaglutide vials bought online without a prescription.
- Hoj and colleagues, 2021: seized peptide products tested by a forensic lab.
- Ho and colleagues, 2012: what TB-500 is, from a racing lab.
- Moiz and colleagues, 2026: doctors' warnings about unregulated injectable peptides in people.
Other sources, named but not linked
- A racing-industry group's undated bulletin on lab testing of products labeled "TB-500".
- A developer's own announcements about a GLP-1 implant for cats, dated April 15, 2025 and December 2, 2025.
- A veterinary reference manual's chapter on diabetes in dogs and cats, updated May 2026.
- Approved drug labels for cyclosporine and for the newer cat diabetes medicines, read on the National Library of Medicine's DailyMed site.
- FDA warning letters to online peptide sellers from 2025 and 2026, cited by date only.
Emergency services mentioned in this guide
- ASPCA Animal Poison Control: its own website, as read in September 2026, named here but not linked.
- Pet Poison Helpline: its own website, as read in September 2026, named here but not linked.